Bacterial Parcel Service Discovered

first_imgBacteria send letters and parcels to one another.  Some of them are love letters, some of them are letter bombs.  This amazing packaged system of communication, separate from the mere sending of diffusible chemicals, was described in Nature1 with the title, “Microbiology: Bacterial speech bubbles.”  Stephen C. Winans described what is known about bacterial communication:Many bacteria socialize using diffusible signals.  But some of these messages are poorly soluble, so how do they move between bacteria?  It seems they can be wrapped up in membrane packages instead.   (Emphasis added in all quotes.)He said that two research studies in the same issue of Nature, one on how bacteria talk to their friends, and another on how they attack their enemies, met in an “unexpected convergence.”  One type of parcel, for instance, is “released in bubble-like ‘vesicles’ that also contain antibacterial agents and probably toxins aimed at host tissue cells as well.”    Through this form of packaged communication, a community of microbes engages in “quorum sensing” to detect whether it is alone or surrounded by its own kind or other species.  Some genes only turn on when there is a quorum reached.  One of these Winans mentioned is bioluminescence – turning on the lights.    The parcels can contain chemicals, proteins, toxins and other molecules in a lipid envelope.  The packaging permits delivery of proteins and chemicals that otherwise might be insoluble.  Some bacteria have three separate kinds of signal parcels.  The packages form lipid bubbles around them as they emerge from the bacterial membrane.  These can merge with a friendly neighbor or, depending on the need of the moment, deliver a toxin to an enemy – a package bomb on the scale of bacteria.    To work, the system requires multiple parts: the contents, the packaging, the delivery method, and the response to received parcels.  Winans did not speculate on how this system might have evolved, other than to say, “Various groups of bacteria use diffusible chemicals to signal to their own kind, and this method of communication seems to have evolved independently several times.”1Stephen C. Winans, “Microbiology: Bacterial speech bubbles,” Nature, 437, 330 (15 September 2005) | doi: 10.1038/437330a.This is an interesting phenomenon that deserves further investigation by science and medicine.  Since humans are sometimes targets of the toxins delivered by these vesicles, interrupting or targeting the bacterial UPS might lead to cures for disease.  Was this system originally a beneficial delivery service that got co-opted for harm?  It seems unlikely that a mindless bacterium could come up with such a complex system of interacting parts once, let alone several times, by an evolutionary process of trial and error.    It’s a stunning thought to envision lowly bacteria with a social life and a coordinated, effective package delivery system.  Rather than assuming it arose spontaneously as an opportunistic mechanism for serving the bacterial “self,” perhaps it is best to look at this phenomenon from the vantage point of systems biology (06/15/2005, 06/20/2005).  What role might it play in the bigger picture?    “Attacking and killing enemies” is a metaphor with metaphysical baggage (see “Metaphors Bewitch You,” 07/04/2003).  Another way of thinking about the “parcel bombs” might be with the give-and-take metaphor of action/reaction, feedback/feedforward, agonist/antagonist – i.e., a sensory mechanism of messages and responses that keeps a larger dynamic system in balance (homeostasis).  Such balancing interactions take place at many levels in biology, from interactions between molecules and proteins within the cell all the way up to interactions between higher organisms.  If too much of one side causes pain and suffering, that does not preclude the possibility that, in balance, the operation had a beneficial role.    An evolutionist would undoubtedly study this bacterial UPS as a byproduct of selfish genes at work trying to ensure their own survival.  A design theorist could continue investigating it with just as much curiosity and enthusiasm, but without the tunnel vision of Darwinian self-centeredness.  He or she would ask, in the big picture, what role does it play, and has that role gone awry? (Visited 6 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more

Draw our flag

first_imgDraw a rectangle in a proportion of 3 in the length to 2 in the width – 18cm x 12cm is a convenient size.Using a pencil, divide the rectangle into three equal horizontal stripes.Join the four corners with a diagonal cross.On each side of the diagonal cross, which provides the centre line in each case, draw parallel lines. The distance between each set of lines should be one third of the width of the flag. Join the various lines as shown.Within the V-shaped area, which extends from the corners at the flagpost to the outer edge of the fly, draw a series of parallel lines, the distance between which is in each case one-fifth the width of the flag. Join the appropriate lines as indicated and erase the remaining pencil lines.Colour specifications for the flagTextile coloursGreen: CKS 42 c Spectrum greenBlack: CKS 401 c Blue blackWhite: CKS 701 c National flag whiteGold: CKS 724 c Gold yellowRed: CKS 750 c Chilli redBlue: CKS 762 c National flag blueApproximate Pantone equivalentsGreen: 3415 cGold: 1235 cRed: 179 cBlue: reflex blue cHTMLGreen: #00d400Gold: #d4d400Red: #d40000Blue: #0000d4last_img read more

Bajaj Pulsar NS 160 bookings start in India, to launch next month

first_imgAccording to reports, Bajaj Auto has commenced with the pre-bookings for their latest product, the Pulsar NS 160 in India for an initial token amount of Rs 10,000. As far as speculations go, the new Pulsar NS 160 is not a replacement for the company’s best seller, Pulsar 150 and will be positioned below the Pulsar 180 in India.Design:The Pulsar NS 160 stands out with an aggressive and sporty look. An aggressive front with a muscular tank bearing a 160 design on the side gives this Pulsar’s style a new dynamic. The underbelly exhausts gives it a lean, sleek look that accentuates the iconic naked sport family.Bajaj Pulsar NS 160Engine:The new Bajaj Pulsar NS 160 will come with a 160.3 cc, 4-stroke, oil-cooled DTSi engine that produces 15.2BHP of peak power and 14.6NM of peak torque, mated to a five-speed gearbox.Suspension:The mono-shock with Nitrox rear suspension is carefully designed to maintain a stable riding position at every twist and turn. The sporty-looking, 12-litre fuel tank lets the rider take extended trips while keeping a snug position at all times.Bajaj Pulsar NS 160Dimensions:The new Bajaj Pulsar NS 160 will come with a wheelbase of 1363 mm and measures 2012 mm in length, 803.5 mm in width and 1060 mm in length with a ground clearance of 176 mm. It has a kerb weight of 142 kgs.Safety Features:The power-packed performance is combined with the ultimate standards in safety. The front disc brakes are powered hydraulically and ventilated to absorb hard riding techniques.Bajaj Pulsar NS 160Competition:The new Bajaj Pulsar NS 160 will compete with the likes of  Honda CB Hornet 160R, Suzuki Gixxer and TVS Apache RTR 160 in India.advertisementPrice:We expect the new Bajaj Pulsar NS 160 to come for price tag of Rs 82,000- Rs 85,000 (ex showroom, New Delhi).ALSO READ:Travel to Spiti, Leh with Bajaj Avenger FLG Rides cruising season 2017-18ALSO READ:Bajaj Dominar 400 price hiked by Rs 2,000last_img read more

A SELECTIVE LIFE

first_imgShe’s sitting on the plane…it’s just five hours until the first manager’s meeting of the 2004 National Touch League begins. It’s just five hours until team registration sheets, selection availability sheets and statutory declaration forms begin to pile up on the desk in front of her. It’s just five hours until the questions begin, the excuses for missing forms begin, the unsigned sheets and the general chaos hits home….no need to continue. The thought is just way too daunting. It’s just five hours until…wait, what’s the air hostess doing to her? Man, it’s hot tea, spilled all down the front of her nice clean skirt. And so it begins… It’s the 2004 NTL’s and National Director of Selectors Cathy Gray is looking forward to 10 days of full time selection for National teams and squads. There’s selection for the Youth World Cup 20 years squads, the Australian Talent Identification Program (TIP), National Training Squads (NTS) and Australian Seniors teams. Everyone sees and knows the final outcome of the work that Cathy and her team of 22 other selectors and TI panel here, will do throughout the tournament. What no one really understands is exactly what these incredibly dedicated people will do to reach that final outcome. The selectors, along with tournament officials, will be the first at the fields every day. They will also be the last to leave. And when they get home, they might cook themselves some dinner and sit down with a cup of coffee or a glass of wine, but their folders will come back out and they’ll get back to work. Over the next 10 days these selectors will together watch around 500 games of touch, see around 1600 different players, fill out around 1000 assessment forms, lose around 100 pens, drink at least 2000 cups of coffee, get itchy legs from sitting on the grass, get sunburnt or drenched by rain (possibly both) and just sick of answering the same questions again and again and again. But they love it. And they wouldn’t be here if they didn’t. Just like players wouldn’t play, coaches wouldn’t coach and referees wouldn’t ref. Cathy Gray has been selecting for touch football since 1991, around 13 years now. She describes her journey to the position of National Director as sort of accidental. “I just sort of fell into selecting, they needed someone one day and I was there”, she says. “I ended up on the NSW selection panel, was invited to apply for the ATA selection panel, applied for the position of National Director and then I ended up here.” “The team of selectors we have are very positive and we have great working relationships with each other and the national coaches. There is a lot of trust on both sides.” It’s important for everyone to realise that for these selectors, this isn’t their only job. “We all have other jobs too, just like the players and coaches. Between touch selection and my teaching job I haven’t had a day at home in six weeks”, says Cathy. “The day after NTL’s finish I will be on a 6:30am flight home, I’ll be back just in time to teach my classes at Cheltenham Girls High school.” Despite the crazily hectic lifestyle that being a selector seems to throw at these guys, Cathy admits to absolutely loving what they get to do. “We love to do this, there’s a lot of great personalities in our group and in touch football in general and we enjoy each other’s company”, says Cathy. “To be honest, we just absolutely enjoy it. It’s a lot of work, but very rewarding. Seeing the way the Australian teams performed and what they achieved at the last World Cup makes all the hard work worthwhile. It was just such an honour to be there and be a part of everything.” So when you’re thinking about your NTL players this week or wondering how they’re doing, send up a quick prayer for our selectors who are working away behind the scenes. They deserve it. Rachel Moylelast_img read more

10 months agoBologna director Di Vaio reveals plans to add psychologist for players

first_imgAbout the authorCarlos VolcanoShare the loveHave your say Bologna director Di Vaio reveals plans to add psychologist for playersby Carlos Volcano10 months agoSend to a friendShare the loveBologna director Marco Di Vaio admits they’re hiring a psychologist to work with the players.The Rossoblu sit third from bottom with just 12 points, though earned a credible draw with AC Milan in midweek.“Bologna are thinking about bringing in a figure who can help work with the players on their minds and mentality,” Di Vaio told Il Resto del Carlino newspaper.“He’d be a psychologist more than a mental coach. The last few weeks have been full of pressure and tension. “It’s not always easy to challenge oneself.” last_img

a month agoEx-Liverpool star Sturridge could face another betting ban

first_imgAbout the authorFreddie TaylorShare the loveHave your say Ex-Liverpool star Sturridge could face another betting banby Freddie Taylora month agoSend to a friendShare the loveFormer Liverpool star Daniel Sturridge is in even more trouble regarding betting offences.The Englishman, who is now in Turkey with Trabzonspor, could be facing another ban.Per The Sun, the Football Association is appealing the decision that saw Sturridge get a fine and a six-week ban for breaching betting rules.If The FA are successful, it is possible that Sturridge will get an even lengthier ban.The Association believes that Sturridge should be made an example to ensure that players do not even think about placing bets related to games or transfers that involve themselves.Sturridge told his brother Leon to bet on him signing for Sevilla in the January 2018 transfer window. last_img read more

Production Begins on New Original Drama REX – Coming to Citytv in

first_imgStarring John Reardon as Detective Charlie Hudson, Rex’s partner; Mayko Nguyen as chief of forensics Sarah Truong; Enrico Colantoni as Superintendent Joseph De Luca; and Diesel (a Canadian Kennel Club Grand Champion) as Rex.“We have wanted to make Rex for a number of years and are overjoyed to now be making this with our partners Rogers Media, Pope Productions, and Beta Film, and in beautiful Newfoundland,” said Christina Jennings, Executive Producer,REX / Chairman & CEO, Shaftesbury. “The original series was a ratings hit around the world and we think Canadian and international audiences will delight in the antics of Charlie and Rex.”“Rex is part of our initiative to enlarge our involvement of English language productions. We are thrilled to partner with Shaftesbury, Pope Productions, and Rogers Media, sharing the same vision for this great contemporary re-imagination and the potential for a new addition to this successful franchise. Rex has a cult following and as long-established brand it delivers a unique and steady prime-time success throughout Europe. We are convinced that we can build on the extensive fan-base and enlarge its footprint internationally, especially in North America,” said Oliver Bachert, Beta Film EVP International Sales and Acquisitions.Shaftesbury and Pope Productions Ltd. produces REX in association with Citytv, a division of Rogers Media, and Beta Film GmbH. Beta Film GmbH holds worldwide distribution rights. Produced with the participation of the Newfoundlandand Labrador Film Development Corporation, the Ontario Film and Television Tax Credit, the Canadian Film or Video Production Tax Credit and the Rogers Documentary and Cable Network Fund.“Pope Productions is thrilled to partner with Shaftesbury along with Canadian broadcaster Citytv and international distributor Beta Film to bring the production of REX to Newfoundland and Labrador. We’ve assembled a stellar team and are looking forward to filming throughout St. John’s. This city is a great place to shoot. The crews here are of the highest calibre, our post-production house NIFCO boasts state-of-the-art technology, the scenery is unbeatable, and our hospitality is legendary. We’re very grateful for support from municipal, provincial and federal governments, who recognize the significant economic and cultural contribution the film and television industry makes to our community,” said Paul Pope, Executive Producer, REX / Principal, Pope ProductionsREX is executive produced by Christina Jennings, Scott Garvie, Paul Pope, Ken Cuperus, and Avrum Jacobson, followed by Laura Harbin as Supervising Producer, Julie Lacey as Producer, and Lisa Porter as Associate Producer. Friedemann Goez and Oliver Bachert are Executive Producers from Beta Film GmbH. Episodes are written by Showrunners Ken Cuperus, Paul Aitken, John Callaghan, Jessie Gabe, Avrum Jacobson, Simon McNabb, and Celeste Parr. Episodes are directed by Felipe Rodriguez, Alison Reid, and John Vatcher. From Rogers Media, Nataline Rodrigues, Director of Original Programming, is Executive Producer, Hayden Mindell is Vice President of Television Programming & Content, and Colette Watson is Senior Vice President of TV & Broadcast Operations.Social MediaCitytv Website: CitytvCitytv on Twitter: @City_tvCitytv on Facebook: Facebook.com/CitytvCitytv on Instagram: @city_tvRogers Media PR on Twitter: @RogersMediaPRRogers Media PR on Instagram: @rogersmediaprAbout Citytv:Citytv offers viewers intensely-local, urban-oriented, and culturally-diverse content through its seven television stations inToronto, Vancouver, Calgary, Edmonton, Saskatchewan, Winnipeg, and Montreal, plus the award-winning Citytv Video app. A distinct alternative to other conventional television stations, Citytv delivers an entertaining mix of Canadian and acquired prime-time programming, news, and local-interactive formats with influential brands such as Cityline, CityNews, and Breakfast Television. Citytv is part of Rogers Media, which is a subsidiary of Rogers Communications Inc. (TSX, NYSE: RCI). Visit Citytv.com.About Shaftsbury:Shaftesbury is an award-winning creator and producer of original content for television, film, digital, and brands. Shaftesbury’s current slate includes 12 seasons of Murdoch Mysteries for CBC, UKTV, and ITV STUDIOS Global Entertainment, two seasons of detective drama Frankie Drake Mysteries for CBC and UKTV, and three seasons of critically acclaimed thriller series Slasher for Netflix. Shaftesbury’s digital arm produces original digital, convergent, and branded entertainment projects including the global phenomenon and MIPTV Brand Content of the Year award winner Carmilla, scripted comedy Upstairs Amy for Walmart and Interac®, and supernatural drama Inhuman Condition. Shaftesbury’s branded entertainment division drives profitable engagement with millennials using scripted series, turning brands into executive producers. Recent brand partners include Walmart, Interac, U by Kotex®, and RBC.About Pope Productions:Pope Productions is a St. John’s based media production company, helmed by producer Paul Pope. Recent features and MOWs include the CBC comedy A Christmas Fury and festival favourites Hunting Pignut, Beat Down and Grown Up Movie Star, which scored a Special Jury Prize at Sundance for Tatiana Maslany.  Documentaries include It’s Mental,Heavy Weather Presents, the multi award winning My Left Breast, Legends and Lore of the North Atlantic and Going the Distance. From the historical dramatic miniseries Above and Beyond, to the classic comedy Rare Birds and the outrageous series Drunk and on Drugs:The Happy Funtime Hour, Pope’s rich repertoire reflects its deep commitment to a vibrant production industry both in Newfoundland and nationally.About Beta Film:Beta Film based in Munich/Germany is one of Europe’s leading distributors of licenses rights for TV, HV, new media and theatrical with a portfolio of over 15.000 hours of program and established itself as a producer and co-producer of national and international high end drama. While the Beta Cinema portfolio comprises many Academy Award-nominated and -winning films, Kineos is responsible for licensing German-language rights to 12,000 titles. In the classical-music domain, Unitel is the global leader in the production of audiovisual music recordings, with a film stock of around 1,500 productions. The corporate group also has stakes in several national and international production companies as well as special interest channels. Founded in 1959, Beta Film has been part of Jan Mojto’s company group since 2004. TORONTO , Oct. 11, 2018 – Shaftesbury, Pope Productions, and Citytv announced today that production has begun on new drama series REX (wt). Centred on the partnership between a police detective and his hardworking dog, REX is a procedural drama with a twist. Starring John Reardon (Van Helsing, Continuum), Mayko Nguyen (Killjoys, Fahrenheit 451), and Enrico Colantoni (Bad Blood, Flashpoint), the eight-episode, 60-minute series is based on the long-running, international hit series Rex, a Cop’s Best Friend. Executive produced by Christina Jennings, Scott Garvie, and Paul Pope, the series has begun shooting in St. John’s, Newfoundland and will continue through December 2018.Set in St. John’s, Newfoundland, REX is an action-packed police procedural dramafocused on the partnership between a dedicated detective and his extraordinary former K9 dog. Rex and Charlie are a detective team that combine their individual skills to solve the most puzzling crimes. This is the first English-language adaptation of the highly successful European format that has aired in 125 countries around the world for 18 seasons.“Citytv is proud to add Rex to our robust slate of original series,” said Nataline Rodrigues, Director of Original Programming, Rogers Media. “Now with dramas in production from coast to coast, we are proud to be truly reflective of our unique viewers across the country with premium Canadian content that we think will connect with audiences at home and abroad.” Twitter Advertisement Advertisement (L-R): Diesel as Rex and John Reardon as Detective Charlie Hudson in REX (Photo by Duncan de Young for Shaftesbury; Copyright: Shaftesbury) (CNW Group/Citytv)center_img Advertisement Facebook Login/Register With: LEAVE A REPLY Cancel replyLog in to leave a comment last_img read more

Judge says Papa Johns founder entitled to corporate records

first_imgDOVER, Del. — A Delaware judge has ruled that the embattled founder of the Papa John’s pizza chain is entitled to corporate records that the company has refused to turn over to him.John Schnatter sued Papa John’s International Inc. last year, claiming he needs the records to inform himself in order to fulfil his corporate duties, and to ensure that other directors are doing the same.The company argued that Schnatter, who was pressured to resign as chairman in July, wanted the records to further his own self-interests.The two sides eventually resolved disputes over 13 of 17 categories of documents.The judge ruled Tuesday that the company failed to prove that Schnatter’s purpose for seeking to inspect the remaining four categories of documents was improper.Randall Chase, The Associated Presslast_img read more

BC Chamber of Commerce reports on the Budget 2019

first_imgThe BCCC shares the areas the Budget did not address issues identified by businesses;A commitment to a comprehensive review of the taxation system to make it fair and less cumbersome for businesses.A broad-based commitment to reduce the regulatory burden on businesses. VANCOUVER, B.C. – The BC Chamber of Commerce (BCCC) reports the Budget 2019 leaves business concerns to the side by falling short on addressing fundamental issues that affect B.C. businesses.The BCCC share there were some small wins in the budget, yet the budget failed to address key issues such as global tax competitiveness, reduced business confidence, and a slumping investment in BC businesses.“Our 2018 Collective Perspective Survey showed that confidence in the BC economy is declining in 50% of BC businesses.  “Current tax rates are hurting our ability to compete globally,” says Val Litwin, CEO of the BC Chamber of Commerce. This budget didn’t adequately address productivity or competitiveness in a way that will grow our economy, create meaningful employment, and generate the revenues we need to sustain a healthy prosperous province and country,” Litwin says. The BCCC shares the areas the Budget did deliver in areas significant to BC Businesses;Multiple funding mechanisms to ensure that high-speed internet access is Canada-wide by 2030, with $1.7 billion specifically earmarked for rural, remote and Northern communities.$631.2 million to expand Work-Integrated-Learning (WIL) programs, with a view to create up to 20,000 new WIL opportunities outside of STEM-related fields.$150 million to create new partnerships between government and industry to create up to 20,000 new WIL opportunities.Multiple funding mechanisms to enhance apprentice programs in skilled trades.$3 billion in tax incentives through the SR&ED tax incentive to support business research and development (R&D) in Canada. The program provides a 35-per-cent refundable tax credit to eligible small and medium-sized businesses.center_img A renewed commitment to eliminating inter-provincial trade barriers and mobility.Support for SMEs to find new export opportunities and expand Canada’s ability to diversify its trade.A clear strategy to move the Trans Mountain pipeline forward, given the significant investment made by Canadian taxpayers.Budget 2019 proposals the BCCC share, require more consideration and details before determining the impact on businesses;The Budget identified funding programs to develop “regulatory roadmaps” to address stakeholder issues and irritants. While these efforts align with the BC Chamber’s interest in reducing the regulatory burden on Canadian businesses, the Budget proposals, unfortunately, maintain a lacklustre, made-by-government solution to a made-by-government problem.The new Canadian Training Credit and EI Training Support Benefits to support the up-skilling and re-skilling of Canadians align with the BC Chamber’s recommendations. However, the potential impact on small businesses remains unclear. The BC Chamber needs more information and wants to see a commitment that business is consulted.The Budget offered little new information regarding the national pharmacare plan. The BC Chamber supports focusing on the 10% of Canadians that are uninsured or underinsured and also supports the value of bulk drug purchasing to help British Columbians manage costs.The BC Chamber supports the Global Talent Stream program but would like to see a commitment from the program to bring skilled immigrants to rural communities, where they are often most needed.The BC Chamber network will continue to engage with Federal representatives to prioritize restoring a competitive tax structure, reducing regulatory burdens, and increasing access to skilled labour as critical priorities to maintain prosperity for all British Columbians.last_img read more

Program expansion provides respite funding for special needs children

first_imgSURREY, B.C. – With the expansion of a program, more than 1,300 additional families with children who have special needs will benefit from respite services by qualified caregivers.As of March 31, 2018, approximately 3,900 families were receiving respite services. This program expansion will provide for 1,300 additional families and provide an increase in the base funding amount each family can receive.“We’ve heard how incredibly important respite care is for families,” said Katrine Conroy, Minister of Children and Family Development. “Parents can get so caught up caring for a loved one that they forget to take time for themselves. They often don’t have the luxury of asking a friend, neighbour or relative to step in for them. Respite offers them a chance to recharge and the peace of mind that comes from having a skilled professional they can count on with the training to meet their child’s unique care needs.” Respite funding allows eligible families to purchase services from a qualified person who will care for the child while the parents attend to other family priorities. Services are provided in the child’s home, the respite caregiver’s home or within the community. Eligibility is not based on a specific diagnosis. Children may be eligible for the program if they are assessed as dependent in at least three of four areas of daily living (washing, bathroom assistance, eating and dressing), or have a palliative condition.According to the government, once families become eligible for respite funding, they are also able to access a range of other programs, including access to a child and youth care worker, behaviour supports, parenting skills training, counselling, housekeeping and life-skills programs for children.Government is developing a new plan to better support children and youth with special needs and their families. It will guide how the ministry invests in and delivers services for children and youth with special needs, and will roll out in spring 2020.The $6.3-million boost to the Province’s respite program was announced in Budget 2019, and changes began to come into effect April 1, 2019. Five million dollars is being used to provide respite services for families who had previously been on the waiting list. The remaining $1.3 million is increasing the base annual funding amount each family can receive from $2,800 to $3,080, marking the first increase in respite funding since 1989.For more information on services available; CLICK HERElast_img read more