The Flaming Lips Perform “There Should Be Unicorns” On Colbert

first_imgThe Flaming Lips popped into the The Late Show with Stephen Colbert last night to perform “There Should Be Unicorns” from their recently-released album Oczy Mlody. Never a stranger to the weird, frontman and rainbow-winged Wayne Coyne mounts a horned-unicorn alongside two horse wranglers dressed like astronauts in this performance. With psychedelic visuals, eccentric costumes, and strange music, The Flaming Lips have continued their quest to stay different – and for that, we are grateful.Watch the full performance below:last_img

Three appointed as investigators

first_imgThree Harvard faculty members, the largest number selected from any one institution, are among 26 scientists from across the United States to be appointed as investigators by the Howard Hughes Medical Institute (HHMI).Levi Garraway, associate professor in the Department of Medicine at Harvard Medical School, Pardis Sabeti, associate professor at the Center for Systems Biology and Department of Organismic and Evolutionary Biology at Harvard and the Department of Immunology and Infectious Disease at the Harvard T.H. Chan School of Public Health, and Tobias Walther, professor of genetics and complex diseases at the Harvard Chan School, were chosen for their individual scientific excellence from more than 800 applicants representing a variety of disciplines from institutions nationwide.“Scientific discovery requires original thinking and creativity,” said HHMI president Robert Tjian. “Every scientist selected has demonstrated these qualities. One of the most important things we can do at HHMI is to continue to support and encourage the best discovery research. We don’t know this for certain, but the ideas that emerge from these labs might one day change the world, and it’s our privilege to help make that happen.”HHMI provides each investigator with a full salary, benefits, and a research budget over his or her initial five-year appointment. The institute also covers other expenses, including research space and purchase of critical equipment. Investigators’ appointments may be renewed for additional five-year terms contingent on a successful scientific review.HHMI encourages its investigators to push their research fields into new areas of inquiry, even if that means changing directions in their research. Moreover, they have support to follow their ideas through to fruition — even if doing so takes many years.“Our essential job is to identify and support the best people we can find,” said Erin O’Shea, vice president and chief scientific officer of HHMI and a professor in Harvard’s departments of Molecular and Cellular Biology and Chemistry and Chemical Biology. “If you study the accomplishments of the scientists we have selected, you will find they are an amazing group of talented individuals. Many are already considered leaders in their fields and some have established entirely new fields of research.”Details on the researchers follow:Levi GarrawayLevi Garraway’s research explores how genetic and molecular alterations in tumor cells cause cancers to grow and spread, and how this knowledge can inform new therapeutic avenues. His team’s studies of melanoma and prostate cancers have turned up entirely new classes of cancer-causing genes. In addition, his research group was the first to identify prevalent cancer-promoting mutations in parts of the genome that do not encode proteins. Garraway also studies how tumors become resistant to cancer drugs, and he and his colleagues have used systematic genetic screens to identify how cells become resistant to targeted therapies.“I am so grateful to the HHMI for recognizing our work,” Garraway said. “This award is a testament to the efforts of the amazing people who have worked tirelessly as part of my research team, and to the scientific and career mentors who supported me steadfastly over the years. Going forward, I will use these funds to gain a deeper understanding of how to identify and overcome the mechanisms that cancer cells use to resist treatments that should otherwise eliminate them. We hope that this work will uncover underlying principles that lead to new therapeutic strategies relevant to many cancers in the future.”Garraway’s lab is also a pioneer in the field of precision medicine, adapting genomic technologies to survey patients’ tumors for hundreds of cancer gene alterations to create tumor profiles that can be used to identify the best candidates for clinical trials and, in the future, tailor treatments to individual patients.Pardis SabetiPardis Sabeti uses the evolutionary record embedded in the human genome to inform new understanding of disease. Her computational methods for detecting recently evolved traits have uncovered genetic adaptations that, for example, altered human resistance to malaria, hair and sweat development, and immune responses to bacteria.When Sabeti’s analyses led her to a human gene associated with increased risk of infection by Lassa virus, a devastating pathogen that kills thousands each year in West Africa, she and her colleagues developed a research program for biosafety level-4 (BL-4) viruses in rural parts of Nigeria and Sierra Leone to study the virus and its role in human evolution. In the weeks following last year’s outbreak of Ebola, Sabeti’s team applied the tools they had developed for studying BL-4 viruses to rapidly sequence and analyze 99 viral genomes from infected patients in Sierra Leone. Their data revealed how the virus was mutating and informed strategies for diagnosing the disease and curbing its spread.Tobias WaltherTobias Walther is the first faculty member at the Harvard Chan School to be appointed an HHMI investigator. His research is focused on the molecular mechanisms behind lipid storage in cells. With scientific partner Robert Farese, he has identified more than 200 genes that regulate lipid storage and discovered there are two classes of lipid droplets: small, static droplets and larger droplets that expand as needed. Walther showed how enzymes involved in synthesis of triglycerides (one type of lipid stored in the droplets) locate and engage with the expanding droplets to build new triglycerides. His team also studies how membrane lipids not stored in droplets are kept in balance inside cells. Ultimately, Walther aims to determine how alterations in lipid stores affect physiology and disease.“The appointment by HHMI is fantastic news for us,” Walther said. “The group and I are honored by the recognition of our science. The freedom associated with this appointment will allow us to focus on elucidating the mechanistic underpinnings of lipid storage and homeostasis, and the physiological functions of these processes.”last_img read more

How Tut became Tut

first_img Related A different take on Tut High tech has made ours an era of ubiquitous images — they flash on our phones, computer screens, and TVs, transmitted from around the world with the tap of a finger or the press of a button.But in the early 20th century, the newspaper was the visual information superhighway, and the pictures displayed in London papers in January 1923 exposed the world to long-unseen wonders.A few months earlier, when Howard Carter first peered into the dark antechamber of the millennia-old tomb of the Egyptian Pharaoh Tutankhamun, his colleagues eagerly asked the English archaeologist if he could see anything. Dazzled by the sight, Carter stammered back, “Yes, wonderful things.”Images of some of those wonderful things appeared in print thanks to English photographer Harry Burton, who was working in Egypt on excavations for New York’s Metropolitan Museum of Art.By loaning to the dig the services of one of the best field photographers of the era, museum officials hoped to be rewarded with finds from the tomb, according to Christina Riggs, a professor of the history of art and archaeology at the University of East Anglia and author of the forthcoming “Photographing Tutankhamun: Archaeology, Ancient Egypt, and the Archive.”In a recent talk at the Geological Lecture Hall, Riggs explored connections among archaeology, photography, memory, identity, and scholarship. The lecture was presented by the Harvard Semitic Museum with support from the Marcella Tilles Memorial Fund.Most archaeologists think that “photographs are fact, and that their main and only interest lies in what they show,” Riggs told the crowd. “What interests me however, is what photographs do, and one of the things that photographs did for the discovery of Tutankhamun’s tomb was create that phenomenon that we now know as King Tut.”Riggs explained that newspapers quickly adopted the nickname “to describe this long-lost, little-known pharaoh with so many symbols in his name.” Burton’s evocative photos turned the tomb “into a triumph for British and American archaeology,” she added.,The tomb’s pristine condition was a key factor in capturing the public imagination, said Riggs, as were its many splendors. But the discovery, she added, “also came at a crucial moment in time.”Many felt that the tomb of King Tut, whose reign dates to the 14th century B.C., represented some of the first good news to emerge from Egypt in generations. The country had long struggled to free itself from control by the Ottoman and British empires, and the boy king, part of a long line of pharaohs who had ruled for 3,000 years, became an important symbol of Egyptian self-government. Egyptian writers took up the topic; teachers taught Tut in schools.Helping fuel interest were Burton’s images of Tut’s golden death mask “in just about every different angle,” said Riggs. The photographs “arguably helped make [the mask] iconic. Burton helped create and perpetuate these interpretations.”A further inspection of the camera work, said Riggs, reveals much about the realities of colonialism. Photos by Burton that depicted Carter working alone in the tomb were often staged, she said, and failed to capture the scope of the effort. In particular, the important contributions of four Egyptian workers who helped Burton carry equipment, set up shoots, mix chemicals, and develop negatives went largely unnoticed by the wider world. These workers occasionally appear in pictures showing Burton at work or posing with his camera, but they are uncredited, unnamed. The grown men were simply referred to as the “camera boys,” said Riggs, a label that highlighted “what assumptions and attitudes lay at the core of colonial-era archaeology.”Yet without their help, Burton may not have achieved such stunning results. The assignment required that he capture images of objects before they were moved, after they had been cleaned, and in the intervening stages. Burton’s technique, including his choice to shoot the cleaned objects in front of a fabric screen and his use of glass-plate negatives, enabled him to eliminate shadows and capture the artifacts in the sharpest detail.By 1933, the dig was over, and interest from newspapers had begun to wane. “Tutankhamun was no longer the top story,” said Riggs. In the end, the Metropolitan Museum received no artifacts from the dig despite Burton’s photographs having been the “star attractions” in the press. Still, as agreed, the institution was given a set of his images.Today, copies of Burton’s archive, a record of more than 3,000 negatives and prints, are housed at the Metropolitan Museum and at the Griffith Institute at the University of Oxford, where they remain important sources of scholarship, exhibitions, and public fascination.That enduring legacy might have surprised Burton. The self-critical, self-effacing photographer didn’t consider himself an artist or a scientist, as many of those working on the dig saw themselves, said Riggs. He was just a man from a modest background, she said, and “the guy with the camera.”center_img Egyptian archaeologist shares theory on pharaoh’s lineagelast_img read more

French insurer AXA speeds coal industry exit plans

first_img FacebookTwitterLinkedInEmailPrint分享Reuters:France’s AXA said it was strengthening its climate strategy by committing to exit coal more quickly across a greater number of countries, as policymakers seek a faster transition to a low-carbon economy.AXA said that as an investor it would exit completely from the coal industry across countries in the Organisation for Economic Cooperation and Development (OECD) and the European Union by 2030, and the rest of the world by 2040.In other steps announced on Wednesday, the French insurer said it will put 12 billion euros ($13.23 billion) in “green investments” between 2020-2023.AXA added that as an insurer, it would restrict coal underwriting policy and stop selling insurance contracts, apart from employee benefits offers, to clients developing new coal projects that exceed 300 MW in capacity.The moves by AXA drew praise from some environmental groups. “AXA is leading the way by driving its portfolio of coal down to zero by 2030,” said Regine Richter, Energy Campaigner at Germany-based campaign group Urgewald.More: French insurer AXA to exit coal investments in OECD states by 2030 French insurer AXA speeds coal industry exit planslast_img read more

Off the Beaten Path | Dwayne Parton

first_imgA few years ago Bryson City, North Carolina native Dwayne Parton set out to hike the entire length of the Appalachian Trail, a goal which he accomplished on his 30th birthday. The monumental feat was a dream come true, but it left him wanting for more. Soon after returning from his thru-hike, the sedentary nature of a traditional 9-5 lifestyle became too much too bear, and Dwayne set out on a cross country adventure that eventually took him to the northernmost reaches of North America.  I recently caught up with Dwayne to find out where he is now, what enabled him to realize the kind of adventure-based lifestyle that most only dream of, and to pick his brain about some of the most uplifting experiences, interesting characters, and thrilling adventures he has experienced along the way.[divider]Q & A with Dwayne[/divider]BRO: What inspired you to leave home and take up a life on the road?DP: I felt like I was waiting for life to happen. I kept catching myself coming home to a movie or a video game. I had thru hiked the AT in 2014 and was missing trail life. I liked not knowing what was going to happen, or who I was going to encounter. The newness of each day. I didn’t want to fill my time with entertainment anymore. Sure I continued to do things outside but it wasn’t the same. Being a part of Bryson City Outdoors helped, but I grew restless. After going on a cross country road trip with my friend and author Beth Hardin, I was inspired to take to the road. I’m a freelance web developer by trade, so my office is where ever I am.Sunset on Flattop in Anchorage AlaskaSunset on Flattop in Anchorage AlaskaBRO: What exactly does a freelance web developer do, and what advice would you give to someone who is actively pursuing that career path? DP: It’s really a broad category. I typically build websites for clients using WordPress or some other content management system. I also manage servers, provide maintenance, remove malicious activity(hacks,malware), and help with social media. I love solving problems and that’s my favorite part of the job. I have been building websites since 2007 and have built up a client base that I feel comfortable traveling with. On the road I’ve picked up a few clients, but it’s really hard to grow when you travel. I’m coming to terms with the fact that I can’t take every potential job. It’s hard to say no, but if you get too much work for your lifestyle it’s hard to provide the kind of work your clients deserve. It’s a hard career path to break into at first, but be diligent. Use your personal website as a testing ground. Experiment. If you find something that works well for you then you have something that may work well for a client.BRO: How do you get around? DP: I’ve been converting a Chevy Express for the last 3 months. It has been a huge upgrade from the small truck I drove up in. HWY 1 in AlaskaHWY 1 in AlaskaIt’s the difference between a home and a shelter. I use a Goal Zero Yeti 400 for power and have a small office that I work from when I can’t find a coffee shop. Coffee shops are ideal though, it’s a nice break from the silence of traveling alone.Check out a 360 degree view of Dwayne’s van below. BRO: Where are you from originally?DP: I was born and raised in Bryson City, North Carolina.BRO: Where did your journey begin, and what kinds of places have you discovered along the way?DP: I started July 2015 from Bryson City bound for Prudehoe Bay, Alaska. I didn’t have any intentions to stay there, it was just as far north as a civilian could drive, so I made that my destination. I took my time getting there staying longer in towns that really captured me. Towns like Leadville, CO and Bozeman, MT. I didn’t plan on staying in Alaska very long and then I hiked up Little O’mally Peak in Anchorage. That did it. I knew I needed to stay.Teslin in the YukonTeslin in the YukonBRO: Any favorite destinations?DP: I have so many favorite destinations. Yosemite, the PNW, Bozeman, Jackson Hole, and Leadville to name a few. I love the mountains and being in them. Whether that’s the Smokies or the Chugach. There is something special about them. They make you feel so small. I do love Alaska! It’s more beautiful than pictures can portray, and the Northern Lights will make you feel like a kid again. I stayed there for 7 months and rented a room in Anchorage.In search of the Aurora. Driving Parks HWY all night.In search of the Aurora. Driving Parks HWY all night.BRO: Tell us about your travel companion.DP: Bobby is a Pitt/Lab mix. I have had him since he was a puppy, that’s almost 9 years now. He’s quite the dog, and for me he’s perfect. Low maintenance. He’s happy as long as he gets to sleep in the bed and ride in the front seat. Bobby Sleeping in the VanBobby Sleeping in the VanHe’s not big on long hikes but loves short ones. We hiked Flattop Mountain in March and glisaded down it. You’ve never seen a dog so happy and fearless. Chasing his human down a steep snowy mountain. Snowshoeing on the Williwaw Lakes Trail, Anchorage, Alaska, Chugach MountainsSnowshoeing on the Williwaw Lakes Trail, Anchorage, Alaska, Chugach MountainsThat caught me by surprise because he’s a big sissy most of the time. He loves car rides, which is good because we do that most of the time now. We have quite the relationship and lots of conversations. The conversations are one sided, but he tries to listen, cocking his head from one side to the other. This is usually due to words that rhyme with “hike,” “ride”, or “treat.”Hiked up to the Ballpark from the Williwaw Lakes Trail, Anchorage, Alaska, Chugach MoutainsHiked up to the Ballpark from the Williwaw Lakes Trail, Anchorage, Alaska, Chugach MoutainsBRO: What sort of outdoor activities have you partaken in while out on the road?DP: Hiking has been what I do most. But I’ve learned some knew skills since I started. Fly fishing has been such a joy. I don’t know why I didn’t do it before. There is great fly fishing in Bryson City. This winter I switched from snowboarding to skiing. There was quite a learning curve because for whatever reason I decided I’d start with telemark. Snowshoeing on the Williwaw Lakes Trail, Anchorage, Alaska, Chugach MountainsSnowshoeing on the Williwaw Lakes Trail, Anchorage, Alaska, Chugach MountainsThat made for lots of “fun” frustrating experiences. I thought many times, “Why did I leave my board at home?”, but by the end of the season I was doing pretty well at the ski resort. The backcountry, however, was a very different story. My lines looked a lot like exclamation points and I spent more time trying to get out of the powder than skiing down it. Parks HWY Alaska RangeParks HWY Alaska RangeOn an better note, I picked up rock climbing. What a great sport! The Alaska Rock Gym became my second home, and I met so many awesome people there. Climbing is one of my main draws to the road now. There are some many more places to go and see now.BRO: Can you tell us about some of the most interesting characters you’ve me while out on the road?DP: I’ve met so many. It’s hard to pick just a few. Some are interesting because of their quirks, and others because they are truly adventurers. One man I met has spent over 5 years of his life on Denali. Hope AlaskaHope, AlaskaEven though he’s a guide it’s hard to fathom spending that much of your life there. I also picked up 2 French hitchhikers on my way up to Alaska. They road with me for over 1,000 miles, language barrier included. I introduced them to American essentials like SPAM and 7-Eleven Slurpees. Hope AlaskaHope, AlaskaThey made sure I didn’t miss some important stops on the Alaskan Highway like Liard Hot Springs or the Sign Post Forest. A brief stop at the Bean Broker in Chadron, NE turned into a 3 day stay where the owner, Andie, convinced me to go visit her son and friends in Bozeman. It was so cool. The Bozemanites let me camp in their parking lot while I was there, took me kayaking down the Yellowstone, and even taught me to fly fish.Dwayne and Bobby hanging out at the Valdez Ice Fest with Bridalveil Falls in the backgroundDwayne and Bobby hanging out at the Valdez Ice Fest with Bridalveil Falls in the backgroundBRO: What is the most challenging or trying thing that has happened along the way?DP: I had a crazy experience this winter. The last week in January I went on a short and easy hiking trip with photographer Jackson Ursin to Thunderbird Falls. We were taking photographs of the waterfall when things went really bad. Jackson slipped and fell off a 30+ foot cliff and bounced off the ice right beside me.Camping spot outside of Hope AlaskaCamping spot outside of Hope AlaskaIt was a surreal moment I could have never expected. It was just us out there and he was broken. It was almost 3 hours before he was rescued and in the hospital. I’ll spare you all the details and let you know that after surgery, 5 weeks in the hospital, and lots of physical therapy, he can now walk. I saw him right before I left, and he ran up to me and gave me a hug. That was a huge deal! The whole incident was a serious wake up call. We weren’t out doing anything crazy and things went terribly wrong. Having a buddy with you could be the difference between life and death.View of Denali from FlattopView of Denali from FlattopBRO: Do you have your next destination planned out? DP: At the moment, I just have an area I want to explore more around Montana, Wyoming, Idaho, and Utah. It’s interesting not having a specific destination. It sometimes makes me feel like I don’t have a goal, but I just want to see where the road takes me. You never know who you’ll meet, and I want to be flexible to the possibilities. I’d like to get back up to Alaska, but don’t want to plan that far ahead yet.Buffalo in Yellostone National ParkBuffalo in Yellostone National ParkBRO: What advice would you give others who want to follow in your footsteps and take up the mobile, travel-based lifestyle?DP: It’s easy to romanticize the lifestyle. Don’t take your ideals with you but be flexible learning to love the set backs because the road is full of them. Some nights it’s hard to find a place to camp and others just feel lonely. You have to step out of your comfort zone often. Smile and talk to people. Discover rock climbing because (1) rock gyms are a great place to shower, and (2) you’ll meet some incredible people. Everyone’s journey is different and be prepared to learn a lot about yourself. Have fun!You can follow along with Dwayne’s ongoing adventures by following him on Instagram and visiting his website.[divider]More from[/divider]last_img read more

A Palace revolution

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Ain’t no stopping US now

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Belgium Euthanasia – Unhappy with sex change

first_imgDaily Mail 1 October 2013A Belgian transsexual has chosen to die by  euthanasia after a botched sex change operation to complete his transformation  into a man left him a ‘monster’.Nathan Verhelst, 44, died  yesterday afternoon after being allowed have his life ended on the grounds of  ‘unbearable psychological suffering’.It is understood to be the  first time someone in Belgium has chosen euthanasia after a sex-change, and  comes soon after it emerged that it is now the cause of nearly one in 50 deaths  in the country.Mr Verhelst died after a lethal injection  administered by the same doctor who last year ended the lives of congenitally  deaf twins who were also going blind. read more

6 sachets of ‘shabu’ seized in buy-bust

first_imgThe suspect was detained in thecustodial facility of the Pontevedra municipal police station, facing chargesfor violation of Republic Act 9165, or the Comprehensive Dangerous Drugs Act of2002./PN The 41-year-old Jerry Diaz of BarangayCubay, La Carlota City, Negros Occidental yielded the suspected illegal drugsvalued around P6,000, a police report showed. Diaz was nabbed after he soldsuspected shabu to an undercover officer for P500 around 8:30 p.m. on Monday,the report added.center_img BACOLOD City – Six sachets ofsuspected shabu were seized in a buy-bust operation in Barangay 1 Poblacion,Pontevedra, Negros Occidental. last_img

Rennes president determined not to lose Real Madrid target

first_img Loading… Rennes president, Nicolas Holveck, has said they’re determined not to lose Edourdo Camavinga this summer. Promoted ContentBest & Worst Celebrity Endorsed Games Ever MadeWhy Do So Many Digital Assistants Have Feminine Names & Voices?7 Ways To Understand Your Girlfriend Better9 Talented Actors Who Are Only Associated With One RoleThe Best Cars Of All TimeCouples Who Celebrated Their Union In A Unique, Unforgettable WayTop 10 Tiniest Phones Ever MadeWhich Country Is The Most Romantic In The World?Top Tastiest Foods From All Over The WorldTop 10 Most Romantic Nations In The World14 Hilarious Comics Made By Women You Need To Follow Right NowGreatest Movies In History Since 1982 The 17 year-old midfielder is a target for Real Madrid. “The priority will be to keep our team, which has shown all its talent in this fantastic season,” Holveck told L’Equipe.Advertisement “We’ll have to be smart in the transfer market to improve the team and make it the best we possibly can in order to pass this qualifying round.” read also:Rennes to block Madrid move for Camavinga Rennes are owned by the Pinault family who are billionaires meaning they are under no pressure to sell their best players. FacebookTwitterWhatsAppEmail分享 last_img read more